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How the Hormone Leptin Helps Regulate Appetite I NOVA I PBS

NOVA PBS Official | December 15, 2025



A young man with lipodystrophy receives treatment after researchers find a hormone in a mouse that helps regulate appetite in humans.

Stream “The Truth About Fat” on the PBS app or online now to learn more: https://to.pbs.org/39GoTsc

Produced and Directed by: Sarah Holt
Co-Producer: Jaro Savol
Edited by: Sarah Holt, Jaro Savol
Animation by: Edgeworx

Digital Producer: Angelica Coleman

© WGBH Educational Foundation

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Written by NOVA PBS Official

Comments

This post currently has 25 comments.

  19. @rachaela9701

    December 15, 2025 at 11:39 am

    Dude when you pick up that mouse absolutely NEVER grab a mouse by its tail unless extremely necessary or as a last resort if the mouse tries to escape, but doing that really damages their spine over time!!! Animals matter too!! Although it is understandable somewhat that you had to test on this mouse in order to save this boy, dude at least give the mouse some respect!!! Starting with NOT grabbing him/her by the tail!!! I know this since I did my research and have pet mice.

  22. @SolaceEasy

    December 15, 2025 at 11:39 am

    The DNA self-correcting mechanism in humans has been disrupted – by humans. Dying is a life force mechanism. Keeping everyone alive as long as possible, allowing corrupted genes to, shall we say, proliferate. I have a gene defect too. I would never have kids. My brother has the same gene defect and has passed it on most likely to all five of his children, with some of them breeding as well. All of them have major health concerns. Seems like our major gene bottleneck is on the horizon. Speciation includes attempts at great diversity, followed by the Great Paring, where unsuccessful genetic experiments are no longer supported, allowing those genetic hosts to perish, erasing the mistakes from life.

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