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The DARKEST trend in the U.S. – What no one is telling you.

No Lab Coat Required | May 2, 2025



🟣There’s been a running story in the U.S. – We’re dying earlier than we ever have. For the last few years we’ve seen a growing increase in what we call “early adult death”, encapsulating the ages between 25 and 44. We’ve received news of an ongoing epidemic of drugs, but when you look a little closer, there’s more to the story we may’ve missed. We also explore if Gen X will have better chances once they reach “early adulthood”

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🟣My Personal Notes:
https://quizlet.com/1013951285/the-darkest-trend-in-the-us-what-they-didnt-tell-you-flash-cards/

🟣cites
1) https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2829783
2) https://academic.oup.com/ije/article/53/2/dyae024/7632338?login=false
3) https://academic.oup.com/pnasnexus/article/2/6/pgad173/7185600
4) https://www.jpain.org/article/S1082-3174(96)80076-6/abstract
5) https://www.bu.edu/articles/2025/early-deaths-americans-explained/
6) https://academic.oup.com/aje/article/190/11/2242/6178413
7) https://www.cdc.gov/mmwr/volumes/65/rr/rr6501e1.htm
8) https://www.researchgate.net/publication/330922982_Today’s_nonmedical_opioid_users_are_not_yesterday’s_patients_implications_of_data_indicating_stable_rates_of_nonmedical_use_and_pain_reliever_use_disorder
9) https://pmc.ncbi.nlm.nih.gov/articles/PMC6882374/
10) https://www.iasp-pain.org/resources/fact-sheets/neurobiological-mechanisms-contributing-to-back-pain/
11) https://pubmed.ncbi.nlm.nih.gov/36618547/

🟣Chapters:
0:00 problem
2:15 lmnt
4:17 excess
8:13 pain
12:23 despair
14:43 receptors
16:23 biomarkers
19:22 crisis
22:05 z

Written by No Lab Coat Required

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